Formulation, Development and Evaluation of Ketoprofen Loaded Transethosomes Gel
نویسندگان
چکیده
Ketoprofen ([RS]2-[3-benzoylphenyl]-propionic acid) is widely employed as a non-steroidal anti-inflammatory drug (NSAID). offered in variety of forms the pharmaceutical industry, including coated tablets, capsules, topical gels, transdermal patches, liquid spray, and injection solutions. The purpose present work was to look at possibility transethosomes gel formulations for distribution ketoprofen see effect lipid concentration, ethanol stirrer time affected results. Vesicle size, surface charge, entrapment efficiency, stability studies were characterise transethosomes. viscosity, pH, content, extrudability, spreadability, vitro diffusion containing gel. optimised formulation had an average vesicle size (nm), percent EE, zeta potential (mV) 135.65, 76.65, -39.98, respectively. prepared TG-12 viscosity 3540±15cps, assay 99.05±0.45, extrudability 175±0.25g, spreadability 13.65±0.35 (g.cm/sec), Employed Franz cell method, release from measured determined be 99.12 10 hours. liberate drugs establish exceedingly consistent regulated. ketoprofen-loaded refined, it may now medication its effects. findings revealed that viable choice administration with tailored long-term release. It also improves penetration many medications through skin.
 Keywords: Transethosomes gel, Ketoprofen, cell, NSAID
منابع مشابه
Preparation and Evaluation of Ketoprofen-loaded Calcium alginate beads
Ionotropic gelation method was used to entrap Ketoprofen (KP) into calcium alginate beads. KP is one of the non steroidal anti-inflammatory drugs (NSAIDs); it has a short half life (1.5-2 h) and deleterious side effects on GIT such as irritation and ulceration. Beads were investigated in-vitro for possible sustained drug release and in-vivo as a gastro-protective system for KP. The curing time ...
متن کاملFormulation Development and Invitro Evaluation of Clarithromycin Topical gel
International Journal of Pharmaceutical Sciences Review and Research International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net © Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. Available online at www.globalresearchonline...
متن کاملEtodolac Containing Topical Niosomal Gel: Formulation Development and Evaluation
The present study aimed to investigate the delivery potential of Etodolac (ETD) containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Dicetyl phosphate (DCP) was also added in the niosomal formulat...
متن کاملFormulation and in vitro Evaluation of Dapsone Topical Gel 5%
Abstract Introduction: Dapsone gel (5%) is found to be effective in treating acne. The study was to develop a topical formulation of dapsone in Iran. Objective: Determination of appropriate formulation for generic form of this drug in the treatment of acne. Materials and Methods: Samples of the base of gel were made in the range of 0.3%-5% by dissolving Carbomer 934P in distilled water, and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2022
ISSN: ['2250-1177']
DOI: https://doi.org/10.22270/jddt.v12i1.5177